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Conqer allergies
CONQUER ALLERGIES/ THRUSH/ CANDIDA
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Do you experience sneezing, watery eyes, and itching - sinus congestion, aches and pains - lethargy & inflammation - irritable bowel and digestive upsets? If you do, then you maybe allergic to certain...
Natural Beauty: The Benefits of Holistic Skin Care
What is holistic skin care? It's a regimen that recognizes that your skin is not just the outermost layer of your body it's also a reflection of your body's internal state. Rather than just treating the surface symptoms, such as wrinkles, sallow...
Sun Exposure & UV Rays: The Basic Facts
The human body benefits from sun exposure. And a little bit of tan protects you from the sun. Right? Wrong!
The body does indeed benefit from sun exposure. But a little bit of tan does not necessarily protect you from the sun. Let’s see why.
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The Wonderful World of Vitamins...Part 1
Vitamins are vital if we are to achieve maximum health and
weight loss. An understanding of vitamins and their function in
our bodies can help us to improve our health and supplement our
diet. Vitamins are only needed in relatively small...
Treadmill Choosing Tips
What treadmill model should I choose? – this is the questions more and more people who want to exercise at home are asking themselves. Well it really depends on how much you will use it, where you will use it and how much money you have. When...
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Spironolactone in the treatment of acne
In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might
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increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)
1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.
2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.
3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.
4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.
5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.
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